Infliximab

Ordering Info & Methodology

Test Code

Cerner Synonyms

IFXB

Remicade Level, Infliximab (Reflexes to antibodies-to-infliximab), Remicade, Inflectra, Renflexis, infliximab-dyyb, infliximab-abda, anti-infliximab antibodies, anti-drug antibodies, ATI, IFX

Turn Around Time

Methodology

Analysis performed weekly. Not available as a STAT order.

Infliximab measured by a laboratory-developed mass spectrometry method; Total antibodies-to-infliximab measured by a semi-quantitative ELISA (Immunodiagnostik)

Ordering Guide

IFXB

Specimen Requirements

Sample Type

Collection Container

Alternate Collection Containers

Serum

Red

Gold

2 mL

Add on stability
This is the length of time after sample collection that this analyte is stable. Test can be added to a previously collected sample if the time since collection is less than the add on stability time.

Minimum Volume

Add On Stability

Collection and Shipping Requirements

Collect at trough (immediately prior to the next infusion); Make at least a 2 mL aliquot of serum; Referred-in sites: freeze aliquots and ship on dry ice to St. Paul’s Hospital. The completed requisition MUST be sent with the specimen.

Reference Intervals

Female Reference Interval

Age Category	Reference Interval	units

Male Reference Interval

Age Category	Reference Interval	units

Additional Notes

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Measurement Uncertainty (MU)
Every laboratory value is an estimate of the true concentration of substance. MU is the 95% confidence interval around that estimate. 95% of the time, the true concentration will be within the range of the reported value ±MU. This value is based on analytical variability (precision) and does not reflect other factors such as sample collection and handling which may also affect the result.

Example

Reported sodium = 140 mmol/L
Sodium MU = 1%
Expanded uncertainty = 140 mmol/L ± 1% or 140mmol/L ± 1.4 mmol/L
Interpretation - the true value of sodium in the sample is in the range 138.6-141.4 mmol/L, with 95% confidence.

Measurement Uncertainty

Requirements

Specimen collected at trough

Completed requisition: Requisition (issued Sept 2018)

Test ordered and requisition signed by specialist (e.g. gastroenterologist or internist)

Optional

For non-standard collections and special circumstances, complete “Clinical scenario” section of the requisition to expedite test approval, prevent delays in test reporting and facilitate appropriate test interpretation.