Alpha 1 Antitrypsin Genotyping
Ordering Info & Methodology
Test Code
Cerner Synonyms
A1ATGB
Alpha 1 Antitrypsin Genotyping, A1AT genotype, A1AT phenotype
Turn Around Time
Methodology
30 days
RT-PCR melting curve analysis
Ordering Guide
Specimen Requirements
Sample Type
Collection Container
Alternate Collection Containers
Serum and Whole Blood EDTA
Red and Lavender - Both tubes required
3 mL
Add on stability
This is the length of time after sample collection that this analyte is stable. Test can be added to a previously collected sample if the time since collection is less than the add on stability time.
Minimum Volume
Add On Stability
Collection and Shipping Requirements
Referring Labs: Aliquot and freeze: 1 mL red top serum for phenotype and 1 unopened lavender tube for genotyping. Send on dry ice.
Reference Intervals
Female Reference Interval
Age Category | Reference Interval | units |
|---|---|---|
Male Reference Interval
Age Category | Reference Interval | units |
|---|---|---|
Additional Notes
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Measurement Uncertainty (MU)
Every laboratory value is an estimate of the true concentration of substance. MU is the 95% confidence interval around that estimate. 95% of the time, the true concentration will be within the range of the reported value ±MU. This value is based on analytical variability (precision) and does not reflect other factors such as sample collection and handling which may also affect the result.
Example
Reported sodium = 140 mmol/L
Sodium MU = 1%
Expanded uncertainty = 140 mmol/L ± 1% or 140mmol/L ± 1.4 mmol/L
Interpretation - the true value of sodium in the sample is in the range 138.6-141.4 mmol/L, with 95% confidence.
Measurement Uncertainty
Requires approval. Generally approved only if serum A1AT level is <1.2 g/L.
Panel AATGPP includes A1AT genotyping by melting curve analysis. Will be reflexed to phenotype analysis by isoelectric focusing and/or genotype analysis by sequencing if intial genotype result is discordant with A1AT level or clinical presentation.
Ordering, Shipping, and Interpretation Information