Aldosterone/Renin Ratio
Ordering Info & Methodology
Test Code
Cerner Synonyms
ARR
Aldosterone/Renin Ratio, ARR, Primary aldosteronism screen
Turn Around Time
Methodology
Liquid chromatography mass spectrometry
Ordering Guide
Not orderable alone.
Specimen Requirements
Sample Type
Collection Container
Alternate Collection Containers
EDTA Plasma
Lavender
1 mL
Cannot be added on to previously collected sample.
Add on stability
This is the length of time after sample collection that this analyte is stable. Test can be added to a previously collected sample if the time since collection is less than the add on stability time.
Minimum Volume
Add On Stability
Collection and Shipping Requirements
Freeze. Send on ice pack. Must arrive at SPH frozen. Thawed specimens will be rejected
Reference Intervals
Female Reference Interval
Age Category | Reference Interval | units |
|---|---|---|
≥ 0 y | <1500 | |
Male Reference Interval
Age Category | Reference Interval | units |
|---|---|---|
≥ 0 y | <1500 | |
Additional Notes
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Measurement Uncertainty (MU)
Every laboratory value is an estimate of the true concentration of substance. MU is the 95% confidence interval around that estimate. 95% of the time, the true concentration will be within the range of the reported value ±MU. This value is based on analytical variability (precision) and does not reflect other factors such as sample collection and handling which may also affect the result.
Example
Reported sodium = 140 mmol/L
Sodium MU = 1%
Expanded uncertainty = 140 mmol/L ± 1% or 140mmol/L ± 1.4 mmol/L
Interpretation - the true value of sodium in the sample is in the range 138.6-141.4 mmol/L, with 95% confidence.
3%
Measurement Uncertainty
Value calculated from aldosterone and renin measurements.
ARR≥1500 is a positive screen for primary hyperaldosteronism. This should be followed by a confirmatory test such as a saline suppression test.
Results may be affected if the patient is on any of the following anti-hypertensive medications. Medications should be held for 7 days prior to testing or for as long as is clinically feasible.
Increased ARR if the patient is on clonidine or beta blockers
Decreased ARR if the patient is on spironolactone, ACE inhibitors, ARBs, calcium channel blockers, or doxazosin.