Natriuretic Peptide B Prohormone
Ordering Info & Methodology
Test Code
Cerner Synonyms
LBNP
NT-proBNP, NT-proBNP, BNP (Brain Natriuretic Peptide), Brain Natriuretic Peptide, Natriuretic Peptide N Terminal, ProBNP NT, Pro BNP, ProBNP (B-Type Natriuretic Peptide), BNP NT, NT ProBNP, N Terminal Fragment of B Type, Netriuretic Peptide
Turn Around Time
Methodology
Analyzed within 1 day of receipt. Available on a STAT basis.
Sandwich immunoassay, electrochemiluminescence, Roche Cobas
Ordering Guide
Specimen Requirements
Sample Type
Collection Container
Alternate Collection Containers
Lithium Heparin Plasma
Light Green
Gold, Red
0.5 mL
Six days
Add on stability
This is the length of time after sample collection that this analyte is stable. Test can be added to a previously collected sample if the time since collection is less than the add on stability time.
Minimum Volume
Add On Stability
Collection and Shipping Requirements
Refrigerate. Send on ice pack.
Reference Intervals
Female Reference Interval
Age Category | Reference Interval | units |
|---|---|---|
0 y - <14 d | <6000 | ng/L |
14 d - <12 m | <650 | ng/L |
12 m - <6 y | <300 | ng/L |
6 y - <11 y | <186 | ng/L |
11 y - <15 y | <160 | ng/L |
15 y - <50 y | <125 | ng/L |
≥ 50 y | <300 | ng/L |
Male Reference Interval
Age Category | Reference Interval | units |
|---|---|---|
0 y - <14 d | <6000 | ng/L |
14 d - <12 m | <650 | ng/L |
12 m - <6 y | <300 | ng/L |
6 y - <11 y | <186 | ng/L |
11 y - <15 y | <160 | ng/L |
15 y - <50 y | <125 | ng/L |
≥ 50 y | <300 | ng/L |
Additional Notes
[object Object]
Measurement Uncertainty (MU)
Every laboratory value is an estimate of the true concentration of substance. MU is the 95% confidence interval around that estimate. 95% of the time, the true concentration will be within the range of the reported value ±MU. This value is based on analytical variability (precision) and does not reflect other factors such as sample collection and handling which may also affect the result.
Example
Reported sodium = 140 mmol/L
Sodium MU = 1%
Expanded uncertainty = 140 mmol/L ± 1% or 140mmol/L ± 1.4 mmol/L
Interpretation - the true value of sodium in the sample is in the range 138.6-141.4 mmol/L, with 95% confidence.
7%
Measurement Uncertainty
NT-proBNP values below the upper reference limit effectively rule out heart failure. Do not repeat NT-proBNP if value was <100 within 30 days.
NT-proBNP is affected by renal clearance and will be elevated in patients with renal failure (acute or chronic). In the absence of an established baseline value, the diagnostic utility of NT-proBNP for heart failure in patients with renal failure is limited.
Assay interferences are possible in patients taking high dose (>5mg/day) biotin supplementation.